Database of Retrotransposon Insertion Polymorphism in Human (dbRIP) at http://dbrip.brocku.ca/. Retrotransposons, represented mainly by Alus and L1s, constitute over 30% of the human genome and play important roles in shaping the structure and evolution of the genome and in participating in gene functioning and regulation. Since many types of retrotransposons, particularly Alus and L1s, are still fairly active in the human genome, their recent and ongoing retrotranspositional insertions generate a unique and important part of genetic polymorphism (for the presence and absence of an insertion) among and within human populations. Such types of genetic polymorphism/mutations are also known to be responsible for a variety of human genetic diseases and they are useful genetic markers in population genetics studies due to their nature of identical-by-descent and homoplasy-free. dbRIP is a database of human Retrotransposon Insertion Polymorphism (RIPs), in which RIP data is highly integrated with the UCSC Genome Browser and its human genome annotation data. dbRIP currently contains all known Alu, L1, and SVA polymorphic/mutation insertion loci in the human genome.

Database created by Jianxin Wang and Ping Liang. Last Download from Source: 2011/10/19